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Teaching

Biomedical Sciences - PRINCIPLES OF DISEASE





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Week 4

Lecture outline

Tissues may recover from injury/stress through repair and regeneration, or respond through cellular adaptation. If the insult persists, then chronic inflammation may occur leading to long term damage.

Cellular adaptation 2

Created by Prof. Mike Dixon

Female age 82

Tissue: Stomach

This obese elderly woman had a long history of intermittent upper abdominal pain. She was taking non-steroidal anti-inflammatory drugs (NSAIDs) for osteoarthritis affecting her hips and knees. Two days prior to admission to hospital, she developed more severe, and sustained abdominal pain. She was admitted as an emergency having collapsed at home. On admission she had signs of peritonitis and was in shock. Despite treatment she further deteriorated and died 5 hours later.

Autopsy revealed a perforated ulcer in the anterior wall of the stomach close to the pylorus. Nearby, on the posterior wall, is a large, deep ulcer with evidence of recent bleeding from its base. The section is taken from the stomach wall adjacent to, but not involved by, the larger ulcer.


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