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Teaching

Biomedical Sciences - PRINCIPLES OF DISEASE





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Week 4

Lecture outline

Tissues may recover from injury/stress through repair and regeneration, or respond through cellular adaptation. If the insult persists, then chronic inflammation may occur leading to long term damage.

Chronic inflammation 2

Created by Prof. Mike Dixon

Female age 82

Tissue: Stomach

This obese, elderly woman had a long history of intermittent upper abdominal pain. She was taking non-steroidal anti-inflammatory drugs (NSAIDs) for osteoarthritis affecting her hips and knees. Two days prior to admission she developed more severe and sustained abdominal pain. She was admitted as an emergency having collapsed at home. On admission she had signs of peritonitis and was in shock. Despite treatment her condition continued to deteriorate and she died 5 hours later. The slide comes from the stomach close to, but not involved by, the larger ulcer.

Autopsy revealed a perforated ulcer in the anterior wall of the stomach close to the pylorus (left) with another large, deep ulcer nearby on the posterior wall. The latter shows evidence of recent haemorrhage from its base.


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