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Teaching

Biomedical Sciences - PRINCIPLES OF DISEASE





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Week 4

Lecture outline

Tissues may recover from injury/stress through repair and regeneration, or respond through cellular adaptation. If the insult persists, then chronic inflammation may occur leading to long term damage.

Chronic inflammation 5

Created by Prof. Mike Dixon

Female age 32

Tissue: Large intestine

This woman presented with a one month history of diarrhoea and passage of blood and mucus. She underwent investigations and after a diagnosis was reached, she was treated intensively with corticosteroids and other supportive measures. This treatment failed to control her diarrhoea and her general condition deteriorated. Six weeks after admission she underwent surgery.

This is part of a total colectomy specimen. The mucosa is intensely haemorrhagic and is broken up by irregular ulcers running between the heaped up areas of intact mucosa.


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1474


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