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Teaching

Biomedical Sciences - PRINCIPLES OF DISEASE





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Week 4

Lecture outline

Tissues may recover from injury/stress through repair and regeneration, or respond through cellular adaptation. If the insult persists, then chronic inflammation may occur leading to long term damage.

Healing and repair 4

Created by Prof. Mike Dixon

Female age 81

Tissue: Bone - rib

This woman fell at home and sustained a fractured neck of femur and three fractured ribs. Her general condition was poor and she was treated conservatively but she subsequently developed bronchopneumonia and died 3 weeks after the fall. One of the fracture sites in a rib was taken for histology.

This is the X-ray of a child's femur. It is fractured in two places. The alignment is poor. The upper fracture site is surrounded by a radio-dense 'collar' that corresponds to ongoing repair with new bone formation. This is 'callus' - the specialised repair tissue that develops around healing fractures. The slide is not taken from this case but is at a similar stage of healing.


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