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Teaching

Biomedical Sciences - PRINCIPLES OF DISEASE





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Week 9

Lecture outline

The first lecture will describe some of the common causes and mechanisms of carcinogenesis and will explain the importance of specific genetic alterations such as proto-oncogene activation and tumour suppressor gene inactivation in the evolution of cancer. The second lecture looks at the early stages of neoplasia, such as dysplasia, and how the recognition of early stages can be important in cancer screening.

Biology of Tumour Cells 1

Created by Prof. Mike Dixon

Male age 66

Tissue: Lung

This man, a life-long cigarette smoker, developed a persistent cough and occasional haemoptysis (blood in sputum). He underwent imaging that revealed a left upper lobe tumour. The nature of the tumour was diagnosed from biopsies taken at bronchoscopy. He underwent lobectomy.

This is the lobectomy specimen. There is an obvious neoplasm arising from the left upper lobe bronchus invading surrounding lung tissue.


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