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Teaching

Biomedical Sciences - PRINCIPLES OF DISEASE





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Week 9

Lecture outline

The first lecture will describe some of the common causes and mechanisms of carcinogenesis and will explain the importance of specific genetic alterations such as proto-oncogene activation and tumour suppressor gene inactivation in the evolution of cancer. The second lecture looks at the early stages of neoplasia, such as dysplasia, and how the recognition of early stages can be important in cancer screening.

Biology of Tumour Cells 2

Created by Prof. Mike Dixon

Female age 72

Tissue: Breast

This woman had long been aware of a mass in the breast but had not sought medical attention. It was only when the seepage of blood-stained fluid from the ulcerated tumour became troublesome that she went to her G.P. She soon afterwards underwent mastectomy.

This is a mastectomy specimen in which tumour has ulcerated through the nipple and surrounding skin. Such appearances are described as 'fungating'.


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