This website uses cookies to allow us to see how the site is used. The cookies cannot identify you. If you continue to use this site we will assume that you are happy with this.
If you would like to know more, you can view our privacy statement here.


Biomedical Sciences - PRINCIPLES OF DISEASE

Leeds University Pathology E-learning

Note: This educational material contains graphic images of tissue and disease -
it is only intended for use by medical students and medical professionals.

Table of contents    A to Z Index


There are 20 lectures that include the following topics:

Week 1

Two introductory lectures, the first asks "What is pathology and how is this particular discipline practised?" The second is on the role of the autopsy in establishing cause of death and understanding pathology of disease.

Week 2

Two lectures will introduce cell injury and how cells and surrounding tissues respond to injury. The active or passive death of cells will be presented.

Week 3

The patterns of immune response will be described, concentrating on the role of key cell types such as lymphocytes and macrophages and how abnormal responses can cause disease.

Week 4

Tissues may recover from injury/stress through repair and regeneration, or respond through cellular adaptation. If the insult persists, then chronic inflammation may occur leading to long term damage.

Week 5

Infectious diseases are the commonest overall cause of death worldwide. The first lecture will introduce the students to the types of micro-organism found in health and disease, and describe basic methods of classification. The second lecture will describe the micro-organisms found in health (normal flora). The subsequent clinical symposium will demonstrate the ways in which these micro-organisms can cause disease, and the impact of such disease.

Week 6

Vascular disease is important leading to 25% of all deaths. The first lecture will describe the pathological process of atherosclerosis. The second lecture will describe the pathological sequelae in the major organs.

Week 7

The vascular topics are concluded with descriptions of the pathological processes of thrombosis, embolism, infarction, hypertension and heart failure. These are very common events that need to be understood.

Week 8

The remaining three weeks are devoted to neoplasia which accounts for 25% of deaths in the population. The principles of benign and malignant tumours are described and their classification explained.

Week 9

The first lecture will describe some of the common causes and mechanisms of carcinogenesis and will explain the importance of specific genetic alterations such as proto-oncogene activation and tumour suppressor gene inactivation in the evolution of cancer. The second lecture looks at the early stages of neoplasia, such as dysplasia, and how the recognition of early stages can be important in cancer screening.

Week 10

Interesting host-tumour interactions involved in invasion and metastasis will be described. Also how we describe the point on the journey the tumour has reached (stage) and how much further it is likely to go (prognosis). We will also describe the methods used to judge how quickly the tumour is travelling along the pathway (grade).


The people involved in the production of these pages.